NEW YORK (AP):

Wilting in high heat and humidity, Eugenie Bouchard became the latest top woman to lose at the US Open, ending her streak of making the semi-finals at each Grand Slam tournament this year.

The No. 7-seeded Bouchard, the runner-up at Wimbledon in July, needed a medical time-out and was beaten 7-6 (2), 6-4 yesterday by 17th-seeded Ekaterina Makarova of Russia.

In muggy air with temperature in the high 80s, a trainer checked Bouchard's blood pressure and rubbed plastic bags of ice on her shoulders, arms, and legs, during the changeover after the second set's fifth game.

When action resumed, Bouchard got broken right away to trail 4-2. She broke Makarova and pulled even but got broken at love in the final game to end it. Bouchard's loss means that for the first time since 1977, eight women will have filled the eight finalist slots at a season's Grand Slam tournaments.

Li Na beat Dominika Cibulkova at the Australian Open in January; Li didn't even enter the US Open because of a knee injury, while Cibulkova was stunned by 15-year-old American CiCi Bellis in the first round.

Maria Sharapova edged Simona Halep at the French Open in June; Sharapova lost to Caroline Wozniacki in the fourth round in New York, and Halep went out in the third round against qualifier Mirjana Lucic-Baroni.

Petra Kvitova defeated Bouchard at Wimbledon in July; Kvitova departed in the third round in Flushing Meadows against 145th-ranked qualifier Aleksandra Krunic, who had a chance to pull off another shocker Monday night against two-time major champion Victoria Azarenka.

While Makarova is into the US Open quarter-finals for the second year in a row, Bouchard's early-for-her major exit certainly fits with the way things have gone the past eight days. Of the top 10 seeded women, only two remain: No. 1 Serena Williams and No. 10 Wozniacki.

Williams got to her first Grand Slam quarter-final of 2014 by overwhelming 50th-ranked Kaia Kanepi of Estonia 6-3, 6-3 Monday, winning her first 12 service points with the help of five aces. Because of various upsets, Williams' pursuit of a third straight US Open title and 18th Grand Slam championship has not been interrupted by much difficulty.

Other women eliminated potential match-ups on her half of the field against Kvitova, Bouchard, and past major champions Ana Ivanovic and Sam Stosur, who beat Williams in the 2011 US Open final - the 32-year-old American's most recent loss at Flushing Meadows.

The top-seeded man, Novak Djokovic, played mostly mistake-free tennis, making only 19 unforced errors and facing only two break points - both saved - in a 6-1, 7-5, 6-4 victory over 22nd-seeded Philipp Kohlschreiber of Germany. Djokovic now meets No. 8 Andy Murray, who got past No. 9 Jo-Wilfried Tsonga 7-5, 7-5, 6-4.